Bunyavirus mRNA synthesis is coupled to translation to prevent premature transcription termination
نویسندگان
چکیده
منابع مشابه
Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon.
We have analyzed a cloned beta O-thalassemia (beta O-thal) gene from a patient doubly heterozygous for hemoglobin Lepore and beta O-thalassemia. Studies of 3H-uridine incorporation into beta-globin mRNA in this patient's erythroblasts suggested an intranuclear defect in both beta and Lepore (delta beta) mRNA synthesis, as did S1 nuclease analysis of nuclear RNA. However, the nucleotide sequence...
متن کاملIntranuclear Defect in 9 - Globin mRNA Accumulation Due to a Premature Translation Termination Codon
We have analyzed a cloned #{176}-thalassemia ($#{176}-thal) gene from a patient doubly heterozygous for hemoglobin Lepore and $#{176}-thalassemia. Studies of 3H-uridine incorporation into 9-globin mRNA in this patient’s erythroblasts suggested an intranuclear defect in both $ and Lepore (#{246} ) mRNA synthesis, as did S nuclease analysis of nuclear RNA. However, the nucleotide sequence of the ...
متن کاملWhy is transcription coupled to translation in bacteria?
Active mechanisms exist to prevent transcription that is uncoupled from translation in the protein-coding genes of bacteria, as exemplified by the phenomenon of nonsense polarity. Bacterial transcription-translation coupling may be viewed as one among several co-transcriptional processes, including those for mRNA processing and export in the eukaryotes, that operate in the various life forms to...
متن کاملRho-dependent transcription termination is essential to prevent excessive genome-wide R-loops in Escherichia coli.
Two pathways of transcription termination, factor-independent and -dependent, exist in bacteria. The latter pathway operates on nascent transcripts that are not simultaneously translated and requires factors Rho, NusG, and NusA, each of which is essential for viability of WT Escherichia coli. NusG and NusA are also involved in antitermination of transcription at the ribosomal RNA operons, as we...
متن کاملEffect of premature termination of translation on mRNA stability depends on the site of ribosome release.
Translational stop codons were introduced at various locations in the protein-coding regions of the monocistronic bla and ompA gene transcripts of Escherichia coli, and the decay characteristics of the upstream and downstream mRNA segments were analyzed. Premature termination of translation at codon position 26 reduced the stability of both the translated and ribosome-free segments of bla mRNA,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RNA
سال: 2007
ISSN: 1355-8382
DOI: 10.1261/rna.436607